Fipronil: hazard class and instructions for use. Fipronil: sanitary and agricultural insecticide Fipronil gel

The scale of the terrible crime committed in countries that are considered models of Western democracy, in Holland and Belgium, is only growing. , these are almost all EU members, Canada, 18 states in Asia, Africa and the Middle East. Millions of chickens are destroyed, but fipronil will remind of itself for a long time to come. After all, egg powder (melange), as well as egg white and yolk, are very widely used. food industry(see infographic). And many use them in home cooking.

The well-known food safety specialist, adviser to Rosselkhoznadzor Alexey Alekseenko:

The presence of fipronil in eggs came as a surprise to us and to our EU colleagues. After all, its use is generally prohibited in animals used for food. This is a direct violation of the law, it shows how weak control over the production of products exists in Europe. And this is a serious violation, because fipronil is a broad-spectrum insecticide, that is, an insecticide. In Russia, preparations with fipronil for dogs and cats are allowed as a remedy for ticks, fleas, lice and other insects. It is important that the product is applied to the withers so that the animal cannot lick it off. This was done because of the danger of fipronil - it blocks the most important mediator of the nervous system GABA (gamma-aminobutyric acid), that is, it affects the conduction of impulses in the central nervous system. It is also toxic to the liver and kidneys. And scientists from the United States in an animal experiment showed that it also causes thyroid cancer.

Investigation is underway…

Naturally, everyone is very concerned that such a substance ended up in human food - fipronil is found in millions of eggs. There is it not only in eggs, but also in egg powder, which means in confectionery, in mayonnaise and other products where it or other egg products are added. Moreover, this excites specialists even more than eggs - they are practically not supplied to Russia. But the batch of contaminated egg powder has already been identified and detained.

For me, as a food safety expert, this is a very worrying situation for many reasons, says Alexey Alekseenko. - First of all, pollution is not limited to eggs. Chicken manure also contains fipronil. Since it is used as a fertilizer, it can get into food and fodder plants. This may lead to contamination and drinking water, and reservoirs. The latter is very dangerous for fish - fipronil is extremely toxic to it.

Violations were detected at very large enterprises in Holland and Belgium. During the investigation, documents were found that the companies purchased 3,000 kg of fipronil and made an additional order for 15,000 kg. Imagine how many chickens could get this drug! All this suggests that there may be other equally dangerous violations in the cultivation of animals and the production of products by other companies. This means that control in the EU does not work well.

Holland. Coming everywhere

As the investigation shows, there are two versions of this violation - fipronil was added in Holland due to an outbreak of red ticks in chickens, or simply for prevention. Either way, this is a serious crime.

But that's not all. The Dutch regulatory authorities have identified this earlier and have already eliminated this violation. However, they hid it. And only then, by some miracle, fipronil was discovered in Germany. It is a miracle because no one checks it in eggs - after all, it is forbidden to use it in poultry farming and it simply should not be there.

I recall the recent horse meat scandal in Ireland. Horse meat is not used in the EU in food production. However, after conducting a study on the presence of drugs in products, experts discovered a rare painkiller that is used only in horse breeding. Conducting an investigation, they found out that it was introduced along with horse meat.

But what is the purpose of adding it? After all, edible horse meat is more expensive than usual. In reality, it was cheap non-edible horse meat from an unknown source. Now they are inclined to the version that she is from the USA. It is forbidden to slaughter horses there and there are companies for the care of old horses. Often they are located in Mexico, and it is possible that the meat of these animals ended up in Europe. And that means in agriculture and in the production of products we can expect new scandals and upheavals.

Material prepared by: Yuri Zelikovich, teacher of the Department of Geoecology and Nature Management

The insecticidal agent fipronil is somewhat new among pesticides: this substance was first synthesized by Rhone-Poulenc (France) in 1985, and its starting technology industrial production developed by 1987. After laboratory and field trials in the EU in 1993, the first commercial pesticide with fipronil, Regent, went on sale. Since 1995, fipronil preparations have been undergoing full-scale tests in the Russian Federation. These experiments have not yet been completed, because. the results were mixed, see below. In the EU, fipronil-containing pesticides are currently prohibited from being used on corn, sunflower, other nectar and pollen bearing crops, as well as in livestock for food. In the Russian Federation, pesticides with fipronil Aria, Monarch, Regent and Super are registered for use in agricultural technology. In household sanitation, fipronil is used more widely (see below).

DV

As an insecticide active ingredient, fipronil belongs to the chemical class of phenylpyrazoles. Chemical formula fipronil, its spatial model and the appearance of 95% of the technical product are shown in fig. below. The technical product is a colorless crystalline powder that smells strongly of mold and is poorly soluble in water (1.9 mg/l at pH=5 and 2.4 mg/l at pH=9). Better soluble in non-ionic solvents; solution of technical fipronil is slightly yellowish in color. The saturation vapor pressure of fipronil is small: 3.7E-4 MPa at +25 degrees Celsius. in the air and sunshine in the presence of moisture, fipronil forms metabolites (sulfides, sulfones, amides), which are also insecticides.

Note: crystalline fipronil is easily confused in appearance and smell with powdered penicillin, which requires strict adherence to precautions for handling this substance.

Action

Fipronil is a neurotoxin (nerve poison) of intestinal and contact action. In animals, it binds to γ-aminobutyric acid (GABA) - the most important mediator (regulator) of the passage of nerve impulses through the chloride channels of nerve cell membranes. Without the mediator “turned off” by fipronil, the nervous system becomes overexcited to the point of convulsions, followed by a reaction - paralysis and death.

The specific mechanisms of transmission of nerve impulses to muscles in different groups of animals are significantly different. Fipronil is quite highly selective against insects, incl. resistant to carbamates, pyrethroids and FOS. However, objects of elimination develop tolerance to this substance, therefore, in agricultural technology, pesticides with fipronil are used in alternation to avoid resistance of pests or sporadically in case of their mass invasion. In the fight against resistance, fipronil is used as a replacement drug, because. actively accumulates in plants, and moves slowly along the soil profile and to a depth of no more than 30 cm.

The speed of fipronil as an agrotechnical insecticide is not high - the death of insects begins 8-10 hours after treatment. Efficiency is also not 100% - after a day, up to 15% of pests survive. However, the protective effect is long-term, 14 or more days, and the drug is not washed off by rain. Therefore, on land areas fipronil is most effective against massively migrating pests: when the density of individuals and the total volume of the wandering mass decrease below a certain limit, it stops migration, and the surviving individuals disperse on the ground and, “not feeling the shoulder of their brethren”, quickly die, leaving no offspring, like those isolated from an anthill ants.

Toxicology

Absolutely selective neurotoxin is impossible, because. The nervous system of animals is arranged in general according to the same principles. That's why fipronil is a rather dangerous substance, and its toxicological indicators are by no means mild:

LD50: rats 97 mg/kg body weight orally; 2000 mg/kg skin. Mallard duck 2150 mg/kg; pheasant - 31 mg / kg. CK50 for Japanese carp 0.34 mg/l (96 hours); for daphnia 0.19 mg/l (48 hours). That is, the reaction of specific living organisms to fipronil is very individual.
DSD for humans is 0.0002 mg/kg of body weight.
shoes in the air working area- 0.1 mg / cu. m.
shoes in atmospheric air- 0.0001 mg / cu. m.
MPC in soil - 0.05 mg/kg.
MPC in the water of reservoirs - 0.001 mg / cu. dm.

Note: LD50 - the dose of a substance from which 50% of the experimental subjects die within 24 hours. CK50 is the concentration of a substance in environment, causing the death of 50% of its inhabitants in a specified time.

Symptoms of acute intoxication with fipronil, in order of development and / or degree of poisoning: nausea, causeless excitement, irritability, nervous trembling (tremor), lethargy (severe general lethargy up to lack of sensitivity to pain and sound sleep), convulsions, death. Mild poisoning resolves without treatment if the effect of the drug stops. In case of severe poisoning, treatment is symptomatic; there is no specific anidot. In addition, fipronil is currently the surest candidate for "poison-devils": even mild poisoning with it after a long time affects the kidneys, liver, and thyroid gland. Research in this regard is far from complete (it takes a lot of time), but it seems that fipronil is no safer than the other "devil poison" thiuram (thiram).

Precautionary measures

Insecticides with fipronil for household plots are not produced. Fipronil agricultural preparations are assigned hazard classes 4-2, but this is subject to use by trained and trained personnel. They should be handled and PPE applied in accordance with the pesticide-specific instructions. Keeping in mind the possible long-term post-effects, it is better to consider everything where there is a given DV, the 2nd class of danger, especially since professionals have and resp. PPE.

Fipronil as a household pesticide is used in the form of sprays, gels (ointments) and droppers. Low volatility and solubility in water reduces the danger of such drugs, but we must not forget that fipronil irritates the eyes and mucous membranes, and also has a noticeable skin-resorptive and systemic effect (see above, LD50 for rats on the skin). Therefore, when working with the drug, it is necessary to wear latex gloves with high leggings over the sleeves, a waterproof apron, a respirator or, in extreme cases, a gauze bandage, a hat and goggles. Work clothes and shoes should cover the entire surface of the body.

If the drug gets on the body, you should immediately wash yourself in the shower and then wash the wet clothes. In case of contact with eyes, rinse thoroughly with open eyes under running water. In case of contact with mucous membranes, rinse and consult a doctor. In case of ingestion or if any discomfort occurs during work, also contact a toxicologist without delay.

Keep fipronil insecticides securely locked away from children and animals away from food, medicine, clothing, shoes and household items. Neutralization of the spilled - collect with a rag (which is then destroyed), wipe the place anywhere with a solution of soda and rinse with water. Bait for cockroaches (see below) should be applied in places visited by freeloaders, but inaccessible to children and animals: under the cabinet of a sink or washbasin, behind furniture, washing machine and so on.

Application in everyday life

Fipronil anti-cockroach-gel, Arbalet NEO, Magic drops, Domovoy Proshka, Fumitoks, Eslanadez are registered for use in everyday life in the Russian Federation. For household pest control, they are used in 3 ways (in order of decreasing total volumes of use):

For fumigation from midges - flying blood-sucking insects;
As poisoned baits from synotropic insects - gel;
As an external insecticide for non-food pets.

About avian fipronil

fipronil for nasty

Insecticides against free-living blood-sucking insects (mosquitoes, midges, ktyr flies and bloodsuckers) are available in the form of sprays, plates, spirals and vials for electric fumigators, see Fig.:

Fipronil mosquito spray is generally not a home remedy, but for non-electrified places - cottages, picnic areas, tents, etc. The smell of a weak solution of the drug is not felt by a person, so fragrances are added to the sprays. But their smell is not as nasty as (otherwise you won’t sell it). If there is a lot of midges, with fipronil not for long and overdo it to the point of intoxication. Therefore, in the case of spraying fipronil mosquito spray in a room (especially in a cramped one, for example, in a tent), before people enter it, it is aired until the smell disappears completely: the remnants of the drug that have settled on the walls, floor and ceiling will be enough from midges for the night.

Fumigation with fipronil is much safer and more economical, because. as a result of heating into the air, not so dangerous, but quite effective from bloodsuckers, DV metabolites go out of the grill of the apparatus. Fumigators on plates and spirals are convenient, but plates and spirals are easily falsified. A solution of fipronil with a purity above 90% is colorless, and a counterfeit one is slightly yellowish, and it is easy to distinguish a high-quality bottle from a dubious one, so it is better to use fumigators under the bottles.

From home freeloaders

Gel-like fipronil from cockroaches, ants, earwigs and other synatropic insects is used in the form of ointments and pastes with impurities of attractants (substances that attract freeloaders). It is also effective against herbivorous stink bugs flying into rooms, sometimes found in the houses of bugs-"soldiers" and wood lice. Although the latter are not insects, but land crustaceans, fipronil is deadly for them too.

Fipronil gel preparations from house insects are available in tubes and syringes, see fig.:

They should be used according to the instructions and with the precautions, see above. There are also recommendations for the use of these remedies for silverfish (top right) and flycatchers (bottom).

silverfish and flycatcher

Bait is not effective at all against silverfish: these primitive insects feed on ... house dust. The silverfish “will not fall for the bait”, and it will not bite it with its weak jaws. In general, silverfish are completely harmless, harmless, they do not spread any infection and lead a very secretive lifestyle. It makes sense to fight them if there are too many of them at home, which is extremely rare.

The flycatcher is a scary-looking, but very useful predatory insect from the centipede order. Her lifestyle is fully characterized by the name. The flycatcher and other house insects do not spare: if it even occasionally appears in sight, there will almost certainly not be cockroaches, bed bugs, etc. in the house. Like all centipedes (scolopendra, etc.), the flycatcher is poisonous, but the talk, they say, bit the child, this is either a lie or a panic fiction. The jaws of the flycatcher (centipedes do not have real jaws) are not able to bite through the skin of a newborn baby, and a person is insensitive to its poison. Flycatchers themselves never climb on people, and if they catch her, she tries to get away as soon as possible. But it is possible to kill a flycatcher with insecticidal bait - if it eats a poisoned, but still living insect.

For pets

With insecticidal preparations of fipronil for cats and dogs, the situation is special. There is a failure in the registration system for pesticides: they are neither zootechnical (since animals permanently living in the house are not considered productive), nor sanitary (a domestic dog or cat is not necessary to ensure the livelihoods of its inhabitants), much less agrotechnical. On the other side, harmful effect fipronil has not been recorded on canines and cats, including thoroughbreds (in the sense of maintaining the purity of the breed when crossing). Therefore, insecticides for pets are sold either as veterinary drugs under completely different rules, or, predominately. online, without registration. In Russia, in this way, you can buy imported mono-preparations of fipronil. Which, of course, in no way negates the properties of this active ingredient, the rules and precautions for handling it, see above.

For the treatment of dogs and cats from fleas and ear mites, 0.25% fipronil spray is used under various names. This formulation of the drug poses the greatest danger to people, since the active ingredient is partially sprayed into the air. Therefore, it is undesirable to use simple “pshikalki” BAU (household aerosol packaging, pos. A in the figure). Much safer are sprays with a cap nozzle that limits the area of action of the drug, pos. B.

Processing is carried out in a ventilated non-residential premises using PPE (see above).
Before use for ear mites, it is advisable to give the animal a slight sedative, because. the delicate skin in the auricle from the drug may itch at first.
The sprayer with a jet limiter is brought to the animal's hair so that the edges of the cap move the awn apart without touching the underfur - the most irritable of them react calmly to the stirring of the awns of the coat.
Spraying is carried out strictly according to the scheme and norms for a given species / breed according to the instructions for a specific preparation.
At the end of the treatment, they stay with the pet in the room for her for half an hour.
If the animal tolerates loneliness, leave it in the processing room for 2-4 hours before bringing it back to the living rooms.
Otherwise, they take them out for a walk, not less than an hour. It is desirable to walk in warm sunny places so that the solvent dries faster, and the non-absorbed remains of fipronil are converted into its metabolites.
During the week, they carefully observe the pet and do not allow children to play with it. In case of any anomalies of behavior or deterioration of health, he and / or their animal is shown to the veterinarian, and the children are brought to an appointment with a toxicologist.
Re-treatment (if necessary) is carried out no earlier than 7 days after the first, unless otherwise indicated in the instructions for the preparation.

Video: about treating animals with a flea and tick spray

and possible errors

Video: Mistakes when handling pets

What if it itches?

Repeated use of external insecticides in case of severe infestation often causes scabies in animals and other undesirable side effects, see for example. video clip:

Video: side effects of flea and tick spray

Causes - skin irritation with a solvent or accumulation of AD residues in the pores of the skin and sweat glands. In the first case, the animal begins to itch intensely shortly after treatment. With the accumulation of DV, it itches every now and then after a few days. Scabies from the solvent will soon pass (if it has not reached strong scratching). "Cumulative" scabies gets worse over time.

Recently, preparations with fipronil of the Lux series have been intensively promoted on the Internet, supposedly not forcing animals to itch. Judging by the commercials, in this case the solvent has been replaced. A long extensive experience with the use of fipronil "lux" has not yet been accumulated, and it is not yet possible to judge whether its active ingredient does not accumulate in the skin.

Finally

Fipronil products for pet control generally work better than flea collars. But when using them, you need to remember: fipronil causes resistance. Therefore, it is necessary to spray and dig their pets with them only at a time in case of severe infection, and for preventive treatments, use insecticides on another chemical basis or combined preparations (eg, with the addition of neonicotinoids).

1. Pyrethrin The most widely used flea and tick treatments have been in use for over 100 years. Pyrethrins are natural water-soluble extracts from chrysanthemum flowers and some other plants of the Compositae family. The possibility of poisoning in animals is quite low, but possible. Symptoms are drooling, trembling and vomiting. To a certain extent, atropine and antioxidants (emicidin, mexidol, ascorbic acid, tocopherol, etc.) serve as an antidote.

I did not find any remedies for pyrethrins. If anyone knows, we unsubscribe.

2. Pyrethroids (Permethrin, Fenotrin, Etofenprox, Flumetrin, Deltamethrin) Synthetic analogues of natural pyrethrins act more slowly and weakly, but have a longer effect. Permethrin should not be used on cats for which products containing etofenprox are marketed.(the packaging should indicate the possibility of use for cats). Pyrethroids are more toxic than natural pyrethrins. Symptoms of poisoning and antidotes are similar to pyrethrins.

Advantix (Permethrin), Scalibor Collar (Deltamethrin), Hartz® UltraGuard Drops (Phenotrin)

3. Phenylpyrazoles (Fipronil, Piriprol) Pretty new group. Leads to paralysis and death of bloodsuckers. Moderately toxic to warm-blooded animals Applicable to both dogs and cats! May cause arousal and aggravation motor activity up to intense central convulsions. It should be used with caution in any form of convulsive seizures, because. is a GABA antagonist. There is no specific antidote! Symptomatic antidote are high doses of GABAergic drugs (picamilon in the form of injections) and anticonvulsants, with the possible exception of carbamazepine (finlepsin, tegretol), due to the fact that it is a sodium channel blocker and can increase the effects of poisoning.

Frontline Spot On (fipronil), Bars (fipronil), RolfClub Spray (fipronil), Prac-tic drops (pyriprol - praised for allergy sufferers). Only Frontline is allowed to be used by pregnant bitches, puppies and debilitated dogs.

4. Formamidins (Amitraz) A brand new poison. Moderately dangerous to warm-blooded animals not recommended for puppies, small breed dogs and cats. May cause lethargy and depression, muscle weakness and ataxia, slow heart rate and lower blood pressure, diarrhea and vomiting. The antidote is adrenoblockers (atipamezole, also known as antisedan, dihydroergotoxin and other derivatives of ergot alkaloids, nicergoline, also known as sermion), antioxidants (mainly ascorbic acid).

ProMeris Duo (powerful new contraption)

5. Avermectins(Ivomectin, Ivomek, Abamectin, Doramectin, Ivermek, Selamiktin, domestic preparations of the Aversectin series) Avermectins act on fleas, ticks, including indestructible Demodex and many helminths, including those that live in the bloodstream (Dirofillaria and their larvae - microfilariae, opisthorchiasis ). Almost the only group about which it is said that these poisons enter the blood. Breed groups that simply do not tolerate the action of any avermectins on their body: collie, sheltie, chow-chow, shar-pei. Symptoms of poisoning are primary muscular excitation, which is quickly replaced by depression and paralysis, and cardiac activity and respiration are also inhibited. There are no specific antidotes, drugs that relieve symptoms are used.

Lawyer (ivomek)

6. FOS (Thiophos, Karbofos, Methylmercaptophos, Dichlorvos, Methylcarbamate, Propoxur) FOS and carbomic acid derivatives are very effective for the destruction of all arthropod reptiles, but, unfortunately, highly toxic to dogs and cats(and a person should not use these compounds instead of snacks for beer). It is strictly forbidden to use for cats! Propoxur is able to accumulate in the body, so it is prohibited for use in farm animals. If you have been using drugs based on propoxur for some time, it is advisable to periodically switch to protection products based on other active ingredients. Symptoms of poisoning include excessive salivation, constriction of the pupils, muscle tremors and convulsions followed by muscle weakness and paralysis, which can also cause respiratory arrest. A specific antidote is atropine and acetylcholinesterase reactivators (diethixime, dipiroxime).

Bolfo spray, Kiltix collar (both propoxur)

7. Repellent esters. Essential oils can be very dangerous too, be careful!! Geranium, clove, lemon and mint oils are effective. Do not use more than 3 drops per 20-40 kg dog. Dilute in a small amount of alcohol/vodka or base oil. Apply evenly throughout the coat. Only REAL oils are effective, dear. In pharmacies, 90% are synthetic, they are of no use. Can only be used as an additional measure. More details about broadcasts on page 3 of the topic.

II. Application, combination, cats
It is known that ticks are hellish creatures and adapt to everything. Therefore, in "tick-active" areas, they no longer rely on one thing. For example, in Moscow Bars and Frontline terribly break through. We are fine for now.
So, if you want to play it safe, then use several means, but ALWAYS FROM DIFFERENT GROUPS! The use of two drugs from the same group leads to severe intoxication. DO NOT COMBINE THE TIME TO START THE USE OF TWO DRUGS For example, they dripped, after a week they put on the collar.
You can speak forever on the topic of the harm of using several different means, but the treatment for piroplasmosis is a uniform killing of the liver. And everyone decides for himself how to poison his dog.

Cats suffer the most from sprays such as Bolfo and collars with substances that are dangerous to them. Drops can be used in fact any, just keep the cat out on the first day. Fipronil (Frontline, Bars) is absolutely safe for cats.

III. Water resistance
Bathing is not reflected in the drops. This only applies to collars and sprays.
We swim with a RolfClub collar. Kiltix and Bolfo on propoxure, it is slightly soluble in water, but still I would not risk it, given that it brings down fish in a pond. We also remove before bathing in the bathroom.
Conclusion - we re-treat with a spray after bathing, we remove the collar for the duration of the bath, except for those on fipronil. Drops are not scary.

IV. How to handle spray and drops
Spray
When treating a dog with a spray, it is necessary to apply it to the entire coat, along the entire length. If the coat is long, comb through. The expense will be large, but otherwise there is no sense. Also make sure that God forbid the dog does not lick this muck!
Drops
Distribute on the skin along the spine to the end of the tail. Do not pour the entire pipette only at the withers!!! Make sure the drops are on the skin and not on the coat.

V. Penetration
Firstly, the fact that you found a tick on a dog does not mean anything. There are practically no deterrents. Basically, they act in the first stage of sucking the tick, and he dies without infecting the dog. That is, it “breaks through” - this is if the treated dog fell ill with piric. Secondly, funds are effective one year, the next is not. Frontline and Bars in Moscow make their way terribly often, we don't have it yet. The most impenetrable according to statistics in general are Advantix, Frontline Skalibor, Bars, Promeris Duo, Bolfo Spray, Kiltix, but this is not one by one. Combine different groups.

VI. Start and end of action
Don't rely on the numbers on the packaging. Avoid forest walks 5 days after the first treatment, do not bathe this time after the treatment with drops. And don't wait for the maximum expiration date (4 weeks). It is better to play it safe and repeat the treatment a few days earlier.

VII. We buy a special twister, we don’t pull it out with our hands !!!

http://www.e1.ru/talk/forum/read.php?f=130&i=1593312&t=1590587&page=0

VIII. Examine the dog every half hour to an hour. Hairy and dark dogs are combed The tick does not suck immediately, but looks for a softer place. Ticks most of all love the muzzle, ears, groin.

And finally, I will quote a post from one forum "At the moment we have Advantix on the withers, Skalibor on the neck and Bolfo-spray before leaving for the fields. PPC !!! there were no sucking stages, but there were heads that were screwed in. In tick-free (practically without grass) - 5-6 pcs per walk. background is subjected to detailed study.When detected, the reptile is clamped with tweezers, and, with tremendous pleasure for me, is martyred in the flame of a lighter.
In the process of parties, earlier, they used the Hartz collar, drops and sprays Bars and Bars-forte. The result is the same. Null. There was no piroplasmosis, but this is a plus for me, and not for the means.

fipronil what is it

Hello! Last year I was on a business trip. They settled me in a hostel of some local enterprise.

The conditions were not royal, but to live for a couple of days is quite tolerable. But the main problem was not even in it.

Already on the first night I met my neighbors - cockroaches. There was no point in starting a fight with them, I only advised the manager to use fipronil. In their situation, only he can help. To make it clearer to you, now I will tell you in detail about fipronil - what it is and how it works.

Fipronil

International name: Fipronil
Appearance: white crystalline powder
Storage conditions: in a dry place
Warranty period: 2 years from the date of manufacture

Fipronil is a widely used insecticide. Fipronil is used to control ants, beetles, cockroaches, fleas, mites, termites, moths, crickets, thrips, weevils and other insects. Fipronil is a white powder with a mildewy odor. Fipronil was first registered for use in the United States in 1996.

Fipronil is a broad spectrum insecticide. Fipronil kills insects when they eat or come into contact with it. Fipronil works by disrupting the normal functioning of the central nervous system in insects.

Fipronil is more toxic to insects than to humans and pets. The specificity of the action of fipronil on insects is explained by the high efficiency of its effect on GABA-controlled chloride channels.

Fipronil is a slow acting poison. After consumption of the bait mixed with fipronil, the poisoned insect will return to the colony or nest. Insect debris can contain enough residual pesticide to kill the rest of the insects in the colony.

In ants, the exchange of bait among colony members promotes the spread of poison throughout the colony. According to the principle of a cascade effect, about 95% of ants and cockroaches are destroyed within 3 days.

Fipronil is highly toxic to fish and aquatic invertebrates. Its tendency to bind to sediment and its low water solubility may reduce the potential hazard to wildlife in the aquatic environment.

Fipronil is toxic to bees and should not be applied to vegetation during bee collection. Harmless to earthworms.

Fipronil is also used as an active ingredient in pet flea products, pest control in cornfields, golf courses and commercial turf.

Health effects from short-term exposure to fipronil depend on how the subject was exposed chemical. Direct, short-term skin contact may cause mild skin irritation.

When fipronil enters the body orally, sweating, nausea, vomiting, headache, abdominal pain, dizziness, weakness and convulsions were observed. Signs and symptoms from short-term exposure to fipronil generally resolve without specific treatment.

Decomposes quickly in soil. The main degradation products in soil under aerobic conditions are sulfone and amide. Residues of fipronil, even when granules are introduced into the soil, spread to a depth of no more than 30 cm.

source: http://www.fmchem.ru/catalog/135

What you need to pay attention to when using the drug

Fipronil is a chem. active substance of pesticides (phenylpyrazole), used in agriculture., in honey. and household processing, veterinary medicine in pest control.

Fipronil refers to drugs with a wide spectrum of action - contact and intestinal poison. It has moderate systemic properties and high residual activity when processing leaves. They can process seeds.

The agent acts as a blocker of gamma-aminobutyric acid, which is responsible for regulating the passage of nerve impulses, due to which the nervous system is disturbed. When excitation is transmitted through cells, acid plays the role of a mediator.

Due to the peculiarity of the mechanical action, this substance can actively fight many types of insects that are resistant to other poisonous compounds.

The insect dies from paralysis within 8-10 hours after exposure to the insecticide. The drug acts as a "protector" for two weeks.

addictive. The presence of drug resistance in various kinds insects suggests that it cannot be used on an ongoing basis.

Application Features:

Effective against orthoptera, beetles and soil-dwelling insects.

Fipronil treats vegetative parts of plants and soil. The drug has a high toxicity.

Abroad, the drug is used to destroy leaf-dwelling and insects living in the soil. A successful result was noted in the fight against locusts (migratory and desert). It is the main drug used in locust persecution.

The drug is also used in medicine and household for pest control:

synanthropic cockroaches;
ants.

Due to the fact that the tool has high level toxicity to warm-blooded animals; for pest control, its use in the form of bait stations or gels is allowed. Due to the systemic actions of the substance, they are also poisoned by ticks and fleas.

Toxicological characteristics

The agent belongs to phenylpyrazoles, which have long-term insecticidal toxicity. Absorbed by plants from soil and seeds. Since it decomposes very slowly under the influence of sunlight, after processing it acts for a very long time.

Attention!

In water, plants and soil, this substance is oxidized to fipronil sulfone.

It moves along the soil very slowly, to a depth of up to 30 cm. One of the most important properties The drug is resistant to rain. According to some reports, the product can be retained on the leaves while maintaining its activity by 75%, even if it rained half an hour after spraying.

Poison action

Poisonous for rats, dermo-active for rabbits. Does not irritate the skin, but is a mild irritant to the eyes.

In animals, it is slowly metabolized, but the substance itself can be detected even a week after the treatment.

Signs of poisoning

Poisoning in an acute degree can manifest itself in severe irritability, lethargy and convulsions. After the drug stops its action, all symptoms disappear.

Preparations based on fipronil are classified as 1 and 3 classes of toxicity for bees, to 2 and 3 for humans.

Fipronil is prohibited to use:

for kittens and puppies under 2 months of age;
for dogs weighing up to 2 kg;
the animals ill inf. diseases or with a weakened immune system;
with increased individual sensitivity to the agent.

It is forbidden to use auricularly with ear scabies or eardrum defects.

What you need to pay attention to when using fipronil:

Personal prevention

when working with poisons you can not smoke, eat or drink;
after finishing work, wash your hands with warm soapy water;
during the day after treatment, the animal should not be touched by hands, you need to protect young children from it.

https://dezplan.ru/deystvuyushchee-veshchestvo/fipronil

Active ingredients of agricultural insecticides and acaricides (Fipronil)

Synonyms - Fipronil, Regent, Cosmos, Adonis
In English - Fipronil
Chemical formula - C12H4Cl2F6N4OS
Chemical class - Phenylpyrazoles
Preparative form - 80% Water-dispersible granules, 4% Emulsion concentrate
Route of Entry – Enteric pesticide, contact pesticide, systemic pesticide
Action on organisms - Pesticide, insecticide
Methods of application - Spraying
CAS Number - 120068-37-3

Fipronil -4-[(1R,S)-(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile] is a chemical active ingredient of pesticides (phenylpyrazole class), used in agriculture and in the practice of medical, sanitary and household pest control to control with harmful and synanthropic insects, as well as in veterinary medicine.

Physical and chemical properties

IN pure form is a colorless crystalline powder with a musty odor. Thermally stable, in the presence of metals is not destroyed, at pH 5-7 is not hydrolyzed, stable; at pH=9 it is hydrolyzed by 50% in 28 days. Decomposes slowly in sunlight.

Physical characteristics:

Molecular weight 437.2;
The melting point of a pure substance is 200-201 °C;
The melting point of the technical product is 195.5-203 °C;
Saturated vapor pressure (25 °C) 3.7 10-4 MPa (2.8 10-9 mmHg);
Solubility in water at pH=5-1.9 mg/l; at pH=9-2.4 mg/l;
T0.5–28 days.

Action on harmful organisms

Fipronil is a broad-spectrum contact and intestinal insecticide with moderate systemic properties and good residual activity in the treatment of leaves, and can be used for treatment and treatment of seeds.

The mechanism of action of fipronil is to block gamma-aminobutyric acid (GABA), which regulates the passage of a nerve impulse through the chloride channels in the membranes of nerve cells, which disrupts the functions of the nervous system. GABA in the system of excitation transmission through nerve cells, like acetylcholine, plays the role of a mediator.

The peculiarity of the mechanism of action explains the effectiveness of the active substance against populations of insects resistant to FOS, pyrethroids and carbamate compounds.

It has a high degree of affinity for -4-phenyl-4-n-propylbicycloorthobenzoate, which ensures the selectivity of the action of fipronil on insects. The death of insects occurs from paralysis 8 hours after the insecticide enters the insect's body as a result of overexcitation of the central nervous system.

The duration of the protective action of drugs based on fipronil is about 14 days.

resistance. The presence of tolerance to fipronil in different populations and races of insects indicates that it should not be used for a long time, this insecticide is an excellent component of insecticide rotation schemes, including when used as food baits.

Pesticides containing Fipronil

For agriculture:

Adonis, KE (registration expired)
Monarch, VDG
Regent, VDG

For medical, sanitary and domestic use:

Anti-cockroach gel, gel bait
Magic drops, gel (mixed pesticide)
Brownie Proshka, gel
Fumitox, gel
Eslanadez, gel (mixed pesticide)

Application

In agriculture. The active substance is effective against pests from the orders of Orthoptera and Coleoptera, as well as soil-dwelling pests. Active as a soil insecticide and for the treatment of the vegetative part of plants. However, the scope of application of this compound is limited by high toxicity.

Preparations based on fipronil are approved for use against pests of wheat (corn beetle, harmful turtle bug (larvae of younger ages, leech), barley (leaf), potatoes (Colorado potato beetle), pastures, areas inhabited by locusts, wild vegetation (locusts).

Abroad. Fipronil, according to foreign press, is used to control both leaf-dwelling and soil insects.

It has been successfully used in the control of Desert and Migratory Locusts (4.8-11 grams of active substance per hectare), and in 2003 the FAO (Food and Agriculture Organization of the United Nations) included it as the main drug for control of the Desert Locust.

For the purpose of medical, sanitary and household disinfestation, preparations based on fipronil are used to destroy synanthropic cockroaches and ants at objects of various categories: residential, industrial, treatment-and-prophylactic, children's, food.

In medical pest control, due to the high toxicity of the substance for warm-blooded animals, only bait stations and gels are allowed.

Due to their systemic action, preparations based on the active substance are also used in veterinary medicine against fleas and ticks.

Instructions for use

It is common practice that instructions for use of a substance are developed for preparations containing that substance. In order to read the instructions for the drug, you must go to the page of this insecticide (presented on the right).

Table Toxicological data compiled in accordance with GN 1.2.2701-10.

Toxicological properties and characteristics

Fipronil belongs to the group of phenylpyrazoles, characterized by high long-term insecticidal toxicity. Can be absorbed by plants from soil and seeds. Due to the slow decomposition in sunlight after spraying, a long-lasting effect is ensured. In plants, soil and water, the compound is oxidized to fipronyl sulfone.

In the soil for 30 days or more, the corresponding sulfide is formed (during the reduction of the sulfoxide group) and amide (due to the hydrolysis of the nitrile group). Fipronil is degraded in soil under aerobic conditions, while its metabolites are degraded under anaerobic conditions. It moves slowly along the soil profile, to a depth of no more than 30 cm.

The metabolites formed in the environment: sulfide, sulfone and sulforide also have an insecticidal effect.

An important property of preparations based on fipronil is their resistance to rain washout. Tests carried out in the Ipatovsky district of the Stavropol Territory showed that the Regent preparation was retained on the leaves and maintained an efficiency of 75% even if it rained 40 minutes after treatment.

toxic action. LD50 for rats 97 mg/kg; LD50 dermal for rabbits > 2000 mg/kg. Does not irritate the skin, slightly irritates the eyes. In animals, it is gradually metabolized, but the labeled active substance is detected even 7 days after treatment.

Attention!

Symptoms of poisoning. Acute fipronil poisoning is manifested in increased irritability, tremor, lethargy, convulsions. After the cessation of exposure to the drug, the symptoms disappear.

Hazard classes. Preparations based on fipronil belong to the first and third hazard classes for bees and to the second and third hazard classes for humans.

History of receipt

Fipronil was synthesized in 1987. In Russia, tests of preparations based on fipronil have been conducted since 1995. It was tested in 1995 in the area of Lake Baikal against a locust complex including 10 species of Gomphocerinae. Fipronil caused 81-87% mortality in orthoptera after 24 hours.

In 1993, on the basis of fipronil, the first commercial drug for medical disinsection appeared - Goliath gel (poisoned baits).

source: http://www.pesticidy.ru/active_substance/fipronil

FIPRONIL for animals

International non-proprietary name (INN): BAN accepted for use in the UK.

Included in the following preparations for animals:

BLOKHNET DROPS - solution for external use, reg. No.: PVR-2-5.6/01768 dated 12/11/2006, NVP ASTRAPHARM LLC (Russia) - manufactured by: NPK SKiFF LLC (Russia)
IN-AP COMPLEX - solution for external use, reg. No.: PVR-2-2.0/02530 dated 04/15/2010, NVP ASTRAPHARM OOO (Russia), manufactured by: NPK SKiFF OOO (Russia)
FIPRIST® SPOT ON - solution for external use, reg. No.: 705-3-14.15-3012 No. PVI-3-8.0/03272 of February 19, 2016, KRKA d.d., Novo Mesto (Slovenia)
AMIT FORTE - solution for external use, reg. No.: PVR-2-5.8/02197 dated 08/30/2008, Agrovetzashchita NVC LLC (Russia), manufactured by: AVZ S-P LLC (Russia)
INSECTOACARICIDAL DROPS BARS® FORTE - solution for external use, reg. No.: PVR-2-7.7/02043 dated 11/26/2007, Agrovetzashchita NVC LLC (Russia), manufactured by: AVZ S-P LLC (Russia)
SPRAY INSECTOACARICIDE BARS® FORTE - solution for external use, reg. No.: PVR-2-7.7/02042 dated 11/26/2007, Agrovetzashchita NVC LLC (Russia), manufactured by: AVZ S-P LLC (Russia)
INSECT-ACARICIDE COLLAR BARS® – polymer tape, reg. No.: PVR-2-5.7/02023 dated 19.09.2007, Agrovetzashchita NVC OOO (Russia), manufactured by: AVZ S-P OOO (Russia)
FIPREKS 75 SPOT-ON - solution for external use, reg. No.: PVI-2-2.9/02726 of 04/08/2009, Vet-Agro sp.z.o.o. (Poland)
FIPREKS SPRAY FORTE - solution for external use, reg. No.: PVI-2-2.9/02727 of 04/08/2009, Vet-Agro sp.z.o.o. (Poland)
INSPECTOR TOTAL K - solution for external use, reg. No: PVR-3-7.12/02838 dated 06/06/2012, NPF EKOPROM (Russia)
INSPECTOR TOTAL C - solution for external use, reg. No.: PVR-3-7.12/02839 dated 06.06.2012, NPF EKOPROM (Russia)
FIPRIST® SPRAY — solution for external use, reg. No.: 705-3-21.12-1115 No. PVI-3-21.12/03840 dated 09.11.2012, KRKA d.d., Novo Mesto (Slovenia)
FIPRIST® COMBO - solution for external use (for dogs), reg. No: RK-VP-4-3172-16 dated 07/22/2016, KRKA d.d., Novo Mesto (Slovenia)
FIPRIST® COMBO - solution for external use (for cats and ferrets) 50 mg + 60 mg / 0.5 ml, reg. No: RK-VP-4-3173-16 dated 22.07.2016, KRKA d.d., Novo Mesto (Slovenia).

Pharmacological (biological) properties and effects

Fiprist® Spot According to the degree of impact on the body, it belongs to moderately hazardous substances (hazard class 3 according to GOST 12.1.007-76), in recommended doses it does not have a local irritating and resorptive-toxic effect, and causes slight irritation when it gets into the eyes. The drug is toxic to rabbits, as well as fish and other aquatic organisms.

Indications for the use of the drug FIPRIST® SPOT ON. Dogs and cats from 8 weeks of age with:

entomoses;
otodectosis;
ticks (ixodid, cheilitells);
as part of the complex therapy of allergic dermatitis caused by fleas.

Application procedure

Fiprist® Spot It is used in animals by a single topical application of the drug on dry, intact skin using pipettes of various packaging (depending on the type and weight of the animal).

Before treatment, the tip of the pipette is pierced with an inverted cap, the animal's hair is moved apart in the back area (between the shoulder blades) and, pressing the pipette, the drug is applied to the skin at one or more points in the following doses:

The duration of the protective effect of the drug against ixodid ticks after treatment of cats is 15-21 days, after treatment of dogs - up to 1 month. Duration of protective action against fleas: after treatment of cats - up to 1.5 months, after treatment of dogs - 2-2.5 months.

Repeated treatments of animals are carried out according to indications, but not more than 1 time in 3 weeks.

In order to prevent re-infestation of animals with fleas, bedding is replaced or treated with an insecticidal agent in accordance with the instructions for its use.

For the treatment of otodectosis Fiprist® Spot It is instilled into each ear 4-6 drops (drops must be injected into both ears). For even distribution of the drug, the auricle is folded in half and its base is lightly massaged.

The remainder of the drug in the used pipette (based on the weight of the animal) is applied to the skin between the shoulder blades (single treatment). When otodectosis is complicated by otitis, antimicrobial and anti-inflammatory drugs are prescribed.

Features of the action of the drug during its first use and cancellation were not revealed. Violations of the drug regimen should be avoided, tk. this may reduce its effectiveness. If the next treatment is missed, it should be carried out as soon as possible in the same dose.

Side effects

When using the drug in accordance with the instructions side effects and complications in animals, as a rule, are not observed.

With a significant overdose, the animal may experience excessive salivation, muscle tremors, and vomiting. In this case, the drug is washed off with water detergent and apply general measures aimed at its removal from the body.

Contraindications to the use of the drug FIPRIST® SPOT ON: increased individual sensitivity of the animal to the components of the drug (including history).

It is forbidden to use the drug:

sick infectious diseases and weakened animals;
dogs weighing less than 2 kg;
puppies and kittens under 8 weeks of age.

special instructions

Do not wash and bathe the animal in natural waters within 48 hours after treatment, and also apply the drug to wet or damaged skin.
Auricular use of the drug (with ear scabies) is not allowed when the eardrum is perforated.
With increased individual sensitivity and the appearance of allergic reactions, the drug should be washed off with soap and water or zooshampoo and, if necessary, desensitizing therapy should be carried out.
Fiprist® Slot It should not be used in conjunction with other insecticides and acaricides for the treatment of animals.
The drug is allowed to be used in animals intended for breeding, as well as pregnant and lactating females.
The drug is not intended for the treatment of productive animals.

Measures of personal prevention

When working with the drug Fiprist® Spot It should be observed general rules personal hygiene and safety measures provided for when working with medicines.

Do not smoke, drink or eat while working. At the end of work, wash your hands with warm water and detergent. Within 24 hours after treatment, the animal should not be stroked and allowed to approach small children.

Persons with signs of allergic, respiratory and skin diseases should not be allowed to work with the drug. People with hypersensitivity to the components of the drug should avoid direct contact with the drug Fiprist® Spot On.

In case of accidental contact with the drug on the skin or mucous membranes, it should be immediately removed with a swab and then washed off with water and detergent; in case of ingestion - give a few glasses of warm water to drink, enterosorbent and, if necessary, contact a medical institution (have a label or instructions for use with you).

When destroying an unused drug, it should not be allowed to enter natural reservoirs and sources of drinking water.

Terms and conditions of storage

The drug should be stored in the manufacturer's sealed packaging, separately from food products and feed, protected from direct sun rays, out of the reach of children at a temperature of 0 ° to 25 ° C. Shelf life, subject to storage conditions, is 3 years from the date of production.

It is forbidden to use the drug after the expiration date. Unused medicinal product disposed of in accordance with legal requirements.

source: https://www.vidal.ru/veterinar/molecule/fipronil

Medicines for animals. Fipronil (spray)

The information posted on this page is for informational purposes only and should not be used for self-treatment! Before using drugs, it is MANDATORY necessary to consult a specialist!

This veterinary drug practically not absorbed through the skin of animals. It accumulates in sebaceous glands, whereby long time protects animals from insect-acaricidal diseases.

For whom: given to cats and dogs.

Vacation form: this drug in the form of a clear (or purple) solution is packaged in special bottles with a sprayer, with a volume of 250 or 100 ml. The solution has a specific odor.

Attention!

Dosage: Fipronil in the form of a spray is used externally. Shake the medicine bottle thoroughly beforehand. Spraying is carried out against the growth of the animal's hair, from a distance of 10-20 cm. The bottle with the drug should be held vertically, trying to moisten the skin and hair of the pet abundantly and evenly.

To speed up the penetration of the drug into the skin, it is recommended to rub it lightly with rubber gloves. The approximate dosage of the drug is 3-6 ml for every 1 kg of animal weight.

Animals should not be allowed to lick this insecticide-acaricide off the surface of their fur or skin. You can wash your pet (or allow him to swim in water bodies) no earlier than 48 hours after using the medicine.

Restrictions: do not use this drug for animals under two days of age. It is not recommended for use on debilitated cats and dogs. Some pets use this tool causes allergic reactions.

Licking off the drug can cause symptoms in the animal such as increased salivation, skin erythema, itching, and in rare cases, vomiting and difficulty breathing. This drug is contraindicated in rabbits.

source: http://vet.apreka.ru/?p=fipronil_sprey

Flea and tick remedies

Ticks can transmit many diseases, so tick control is also given great attention. Today's insecticides for pets have made significant strides, with a large number of new flea and tick treatments being produced.

The flea and tick remedy can be in the form of a collar, powder, spray, lotion, shampoo, tablet and drop, the latter has gained the most popularity. However, the main difference between the flea products currently available for sale is the active substance, which provides protection for your animal.

So, today, on the shelves of pet stores, we are mainly offered flea and tick products from Bayer (Advandix, Bolfo, Kiltix), Hartz, Beaphar, Frontline, Promeris, Stronghold and domestic preparations Bars, etc.

The main active ingredients of these funds are the following components.

Pyrethrins (pyrethrins)

Pyrethrins are one of the most widely used insecticides in modern flea and tick treatments and have been used as such for over 100 years. Pyrethrins are natural extracts from chrysanthemum flowers. There are six types of pyrethrins.

All six are used in flea and tick products, however, the active ingredient is usually labeled ‘pyrethrin’ on the packaging of the product, regardless of which type of six is actually used.

Mode of action: Pyrethrins act on nervous system insects and lead to repeated and extensive ruptures of the nerves. The effect is achieved by influencing the flow of sodium from nerve cells.

Uses: Pyrethrins are used to kill ticks, fleas, lice and mosquitoes. Pyrethrin-based products are usually applied directly to the animal. Home flea treatments usually contain pyrethrins, either a combination of pyrethrin and permethrin (see below), or pyrethrins plus a synergist. Synergists are chemicals that enhance the effects of other drugs.

Safety: The possibility of intoxication in animals is very low, but possible. Symptoms of pyrethrin poisoning in animals may include salivation, tremors, and vomiting. Usually the symptoms of intoxication disappear after 24 hours.

Pyrethroids (pyrethroids) (Permethrin (permethrin), Phenothrin (phenothrin), Etofenprox (Etofenprox). Pyrethroids are synthetic components of pyrethrin. This means that they are made in a laboratory and are not natural plant extracts.

The most common synthetic pyrethrins used to control fleas and ticks are phenothrin, ethofenprox, and permethrin. They act more slowly than natural pyrethrins, but have a longer effect.

Mode of action: Pyrethroids, like pyrethrin, act on the nervous system of insects.

Uses: Pyrethroids are used to make flea, lice and tick remedies. Since the action of permethrins is longer than natural pyrethrins, they are usually used in sprays, shampoos to increase the time of the protective action.

Permethrins are soluble in oils but not in water. This property is used to produce products that ensure good distribution of permethrin throughout the animal's body and prolong the protective effect, for example, within a month. Permethrin should not be used on cats.

Products for cats contain etofenprox, which is indicated on the packaging as a product for cats.

Safety: Some animals may experience temporary sensitivity to pyrethroids. The symptoms of poisoning are similar to pyrethrin poisoning.

Organophosphorus compounds (organophosphates) and a group of carbomic acid derivatives (organocarbamates)

Organophosphates and carbomic acid derivatives are another class of agents used as insecticides for farm and domestic animals. Organophosphates and carbomic acid derivatives are widely used, such as: organophosphorus (thiophos, karbofos, methylmercaptophos, dichlorvos, diazinon, etc.), carbamic acid derivatives (methylcarbamate, propoxur).

Attention!

Mode of Action: The effect is achieved by blocking the work of protein receptors in insect nerve cells.

Safety: Organophosphates and carbomic acid derivatives are the class of insecticides most likely to cause toxic poisoning in pets. Symptoms in a pet with organophosphate poisoning include: breathing problems, weakness in the hind limbs, increased salivation, tremors in the limbs

Greyhounds and beagles can be overly sensitive to organophosphates, so it is best to use other flea treatments for these breeds.

Imidacloprid (imidacloprid)

Imidacloprid is a new insecticide that belongs to a different class of chemicals and is used in the manufacture of flea products.

Mode of action: Like most insecticides, imidacloprid acts on the nervous system of insects by blocking nerve receptors. This kills fleas but does not work on ticks.

Use: Imidacloprid is usually used once a month as an external flea insecticide for cats and dogs. Imidacloprid mixed with oily solvents is collected in the hair follicles, from where it is slowly released.

Safety: Imidacloprid is a fairly safe substance, but some pets may develop sensitivity to it when used with other components.

Fipronil (fipronil)

Uses: Fipronil is widely used once a month as an external insecticide for cats and dogs to get rid of fleas and ticks. Fipronil mixed with oily solvents collects in the hair follicles, from where it is gradually released.

Safety: In conjunction with other ingredients, some pets may experience temporary sensitivity at the site of application. Some animals may develop more severe sensitivity. In this case, it is better to consult a veterinarian.

Metaflumizone (metaflumizone)

Metaflumizone is an insecticide of the semicarbazone group used in the manufacture of flea products.

Mode of action: Metaflumizone attacks the flea's nervous system by blocking the movement of sodium atoms. This leads to paralysis and death of the flea.

Usage: Metaflumizone is applied topically once a month. It has no effect on ticks.

Safety: Some animals may experience temporary sensitivity at the site of application of the product or more severe sensitivity, in which case it is recommended to consult a veterinarian.

Amitraz (amitraz)

Amitraz is a component that is used to treat demodectic scabies. Amitraz also showed high efficiency when used in dog tick collars. It has no effect on fleas, so it is only used to control ticks. Do not use amitase on cats.

Mode of action: Amitaz belongs to a group of substances called formamidines and is used as an ingredient in anti-mite collars.

Use: Amitaz has proven to be effective against mites when compared to other agents such as organophosphates.

Most ticks die within less than 24 hours, thus preventing transmission of Lyme disease. Amitaz is also used in other flea products as an anti-tick ingredient (check label for details).

The concentration of amitase in anti-mite collars is not high enough to provide prophylaxis against demodectic scabies.

Amitraz should not be used on cats.

Safety: Collars containing amitase are safe for dogs if used correctly. The collar should be worn so that you can slip two fingers between the collar and the dog's neck - no more, no less.

If the collar is worn too tight it can lead to skin irritation. Make sure that the excess collar is cut off so that the dog or other pet cannot reach the end of the collar.

Selamiktin (selamectin)

Attention!

Selamictin is rapidly absorbed at the site of application, enters the bloodstream through the skin, and is distributed throughout the animal's body through the bloodstream.

Safety: Do not use this product on kittens or puppies under 6 weeks of age. Use caution when using this remedy on sick, debilitated, underweight or skin problem animals.

Nitenpyram (nitenpyram)

Nitenpyram has proven effective in controlling fleas in cats and dogs. Distinctive feature nitenpyram-based Capstar flea remedy consists of an oral route of administration. Mode of action: Nitenpyram blocks nerve receptors in fleas.

Use: Nitenpyram is used as an oral insecticide to kill fleas in cats and dogs from 4 weeks of age and 1 kg. body weight. Nitenpyram kills adult fleas on a pet within 30 minutes.

The peak effect after taking the product is approximately 3 hours for a dog and 4 hours for a cat. This is very convenient under certain circumstances such as surgery, transportation, haircuts, etc.

Safety: Nitenpyram is quite safe. It can be used for kittens and for puppies from 4 weeks and older, weighing from 1 kg., As well as for pregnant animals.

Fipronil is an active insecticidal substance with which you can quickly and effectively get rid of cockroaches in residential areas. The product is available in the form of granules or emulsions - in its pure form it is not used for processing. Fipronil is used in combination with other active ingredients that make up gels, baits and sprays.

What effect does the insecticide have on cockroaches

Fipronil is a poisonous component and acts deadly on cockroaches

This substance is a slow-acting poison used in various pest baits. If the cockroach eats the bait or simply comes into contact with it (even if it just runs its antennae over the poison), it is exposed to the insecticide and dies after a few hours. The drug has a strong effect on the nervous system of cockroaches, causing nerve spasms. As a result, the muscles of the insect are paralyzed, which leads to death.

The complete extinction of the entire population of cockroaches occurs after 2 days. During this period of time, infected pests return to their places of establishment and infect others. The dead Prussians are eaten by healthy ones, and thus the poison spreads among the entire colony. One of the main advantages of the drug is a long residual effect that lasts up to 30-35 days.