What is dangerous kagocel. Kagocel – a new generation antiviral drug Kagocel Complications

"Kagocel" is one of the most popular and effective means in Russia: in the USA and Western Europe, this drug is not even sold, but, nevertheless, it is used in many CIS countries, and in Russia, thanks to competent advertising, it has gained a huge “fans”.

The main effect of "Kagocel" is due to the fact that the substances contained in it are interferon inducers: they stimulate the production of their own interferon in the human body. The main "Kagocel" is a gossypol copolymer - one of the cotton pigments, the main mechanism of action of which is the stimulation of the production of interferon, which provides antiviral and immuno-modeling: temperature reduction and antiviral effect.

The exact mechanism of kagocel's effect on interferon production is still unknown. This is one of the reasons for the non-recognition of the drug in the global pharmaceutical market and in medicine in general.

Interferon is a name given to a series of proteins that are secreted by the cells of the body in response to an invasion by a virus. Thanks to the cells, they become immune to the virus, so taking Kagocel is especially effective at the very beginning of the disease, when the virus has not yet spread in the body. Taking this medicine early in the illness often helps prevent further development and spread of the virus.

"Kagocel": side effects and indications for use

The main indication for the use of "Kagocel" is the presence of SARS or influenza in adults and children. Also, "Kagocel" is often used in the prevention of influenza and various respiratory diseases. viral infections, as well as in the treatment of herpes in adults.

"Kagocel" accumulates in the body 24 or 32 hours after administration - mainly in the liver (88%) - and is excreted from the body after 7 days through the intestines (90%) and kidneys (10%). The drug was not detected in exhaled air.

Regarding side effects ... So far, there have been no statistical studies that could confirm the presence of certain side effects Kagotsela (2013).

The effectiveness of the drug was tested mainly by clinical trials in 2000-2003: 1100 people took part in blind studies with placebo-controlled groups.

The results of clinical trials of "Kagocel" were covered only in the Russian press and Russian popular science magazines. The drug and studies conducted in connection with it have not received international recognition: it is not sold in the USA, Western Europe and is not on the list of drugs of the World Health Organization (WHO).

To defeat the first signs of a cold, doctors recommend taking antiviral drugs. In their composition, they have substances that increase immune function, eliminate symptoms and fight the virus. One of these include Kagocel for colds.

Kagocel refers to antiviral agents, produced in the form of tablets. It contains substances that practically do not cause side effects. They are referred to.

Kagocel. The active substance, which is a compound of synthetic origin. Its action is aimed at increasing the work of immune cells.
calcium stearate.
Povidone.
lactose monohydrate.
Starch.

The therapeutic property lies in chemical composition original component. The active substance is produced using a complex multi-stage synthesis of cellulose, which is obtained from polyphenol cotton seeds. The material obtained is filtered off with an organic sodium salt. In its composition, Kagocel has no similar analogues, since its therapeutic effect is based on the use of natural substances.

Proper use of Kagocel for colds brings a good therapeutic effect.

Restoring a damaged immune system.
Strengthening the body's defenses.
The resumption of the production of interferon, which has the ability to recognize the pathogenic flora and respond to it correctly.
Acceleration of the process of death and removal of harmful viruses from the body.
Violation of the reproduction of microbes that are susceptible to this agent.
Inactivation and removal of free radicals that can provoke the appearance of tumor-like formations.

Indications for use of the drug Kagocel

Kagocel for colds is prescribed for children over three years old and adults. The main indications are:

Colds.
Flu.
Herpes.
Chlamydia urogenital character.
Development of pneumonia for complex treatment.
Diseases of the intestinal nature.

The drug can be used not only for medicinal purposes, but also for prophylactic purposes.

Contraindications to the use of the drug Kagocel

Kagocel in its composition has components of natural origin. But it still has a number of contraindications.

Increased susceptibility to the components of the drug.
Lactose intolerance deficiency.
Glucose-galactose malabsorption.

With caution, you should drink the drug during the gestation period. Treatment should be under the strict supervision of a doctor.

The use of the drug Kagocel for colds

The memo states that Kagocel for colds, flu and preventive purposes must be taken orally. In this case, the tablet does not need to be swallowed and chewed. How to take the drug and how much, the attending physician will tell, based on the individual characteristics of the body. The antiviral drug can be taken before or after eating.

The use of the drug by adults involves taking two tablets up to three times a day. This scheme of the treatment process continues for two days. After that, for another two days, you need to take the remedy one tablet up to three times a day. The duration of the treatment course is four days. During this time, the patient must take eighteen tablets.

If an antiviral agent is used for preventive measures The course consists of two stages. The first stage of reception is considered active. At this time, for two days, the patient needs to take two tablets once a day. The second stage is passive and involves a short break that lasts for five days. At this time, the implementation therapeutic effect. After that, the course can be repeated.

The use of the drug for children is based on the age of the child. Children from three to six years old are prescribed medication one tablet up to two times a day for two days. In the next two days, it is recommended to use the drug one tablet once a day. The duration of the treatment course is four days.
For children over six years old, the remedy is prescribed one tablet up to three times a day for the first two days. Further, the medicine should be taken one tablet up to two times a day.

As a preventive measure, children are recommended to drink one tablet once a day. The course lasts two days. After some time, it can be repeated.

Treatment of herpes with Kagocel

Herpes is one of the known viruses that occurs in almost every person. It also occurs, like a cold, due to a weakened immune function. It is believed that Kagocel can help not only with colds and flu, but also with the development of herpes. Many studies have been conducted and it turned out that the use of an antiviral drug along with acyclovir led to the complete elimination of symptoms within three days. At the same time, the number of relapses also decreased by almost two times.

Peculiarities of treatment with Kagocel in children

IN childhood drugs should be taken with extreme caution. In most cases, Kagocel taken can cause an allergic manifestation in a child. This effect occurs as a result of the fact that in childhood the formation of immune function is still in progress. Therefore, doctors rarely prescribe this drug.

Instead, Anaferon or Ergoferon may be recommended. In their composition, they have interferon, which is not alien to the body. As a result, these drugs practically do not cause side effects. Anaferon can be given to children from the first month of life. Ergoferon is recommended for use in children from six months.
Another excellent remedy is Children's Antigrippin. It can be taken by children from one year old, pregnant and lactating women. This drug refers to homeopathic remedies which has no side effects.

With the timely use of antiviral agents for therapeutic or prophylactic purposes in childhood, the development of complications can be avoided. But it should be remembered that the drugs of this group can not be used more than three times a year.

Interaction of Kagocel with other drugs

Kagocel for colds can be taken with other drugs that have an antiviral and immunostimulating effect. It can also be used in antibiotic therapy, because due to the combination of drugs, the therapeutic effect is greater.

In order for the medication to have a greater effect, it is recommended to take it at the first sign of a cold. It is believed that Kagocel is one of the few drugs that can be drunk even with delayed treatment. Indeed, the remedy helps the body recover quickly and avoid complications. But it must be used no later than the fourth day of illness.

It is also worth noting that Kagocel has no analogues, since it contains unique components.

There is no doubt that the fathers-inventors of kagocel believe in the miraculous power of their remedy, but not in terms of improving the health of the population, but exclusively in the ability to bring money. In 2013, Kagocel outperformed anaferon and arbidol, which are close in terms of group affiliation, "fuflomycins", capturing 19% of the market for "anti-influenza" drugs - 12.5 million packs. Isn't it famously for the "interferon inductor" molded from toxic polyphenol of cotton and cellulose.

Kagotsel was very lucky that he was invented by the director of the N.F. Gamalei Felix Ershov, together with Vladimir Nesterenko, head of the department of immunology, accountable to him. Kagocel was lucky that the academician and his colleague had their own Nearmedic Plus corporation and connections. Connections in practice and scientific world, which made it possible to quickly conduct clinical trials with a guaranteed positive result, the effectiveness of the trials and the speed of introducing the drug into practice are largely due to the fact that high-quality laboratory glassware was used. Ministerial relations ensured the introduction of the drug into the Vital and Essential Drugs.

As for the scientific justification, not a single domestic drug has been tested on such a number of patients as Kagocel - two thousand. True, all studies were not without a powerful conflict of interest - the participation of authors-producers, but at that time, interest in the results was not prohibited. How not to trust epidemiologists-immunologists - since they said that it is useful, it is. And do not care that interferon has a therapeutic effect if it is millions of units, and the body is able to produce only a few dozen, and even then not everyone.

And now, on the threshold of 2012, kagocel, like a nanomedicine, is taken under the protection of the state corporation Rosnano, allocating 1.2 billion rubles only for intellectual property - the kagocel trademark. Duet of Nearmedic and Rusnano is building production line in Obninsk, flooding the country's pharmacies useful tool reducing the incidence of influenza and SARS. Rosnano did not last long, in December 2013 it was announced that it was selling its share to the same founding fathers of the facility. The Moor has done his job - he has rebuilt production, the Moor can leave. But kagogocel was that rare project of unprofitable Rosnano, which brought 41.1% of the profit.

Verily, the hen laid golden eggs to all who touched it. The Nearmedic Plus empire grew with a turnover of 1.9 billion rubles in 2011. With just one drug, the network of Nearmedic Plus medical centers, the production of reagents for medical research Biopharmaholding, and the Newest Medicine, which treats patients with stem cells, grew up. Then still a minister, Golikova, in a pharmacy raid, always inquired about the stocks of arbidol and kagocel.

An attempt by competitors to knock down sales with assurances of corruption along the line of male power turned out to be fruitless. Even the starving heroes of the NTV television project Ostrov had only Kagocel, shampoo for horses and cream for cows in abundance - three most important and equivalent products. Everything ingenious is simple: “We took cellulose, this is a polymer from cotton, we took another certain substance obtained from cotton, combined it with cellulose and got a polymer. It is called "Kagotsel". In the hands of a master, even a handful of dust can turn into gold. The Russians should be thankful that the founding fathers failed to invent a second such kagocel.

The article was prepared and edited by: surgeon

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Today, more and more often you can hear that doctors prescribe Kagocel for colds. It is Russian, it is not registered in the USA, there is no information about Kagocel in the World Health Organization. Among other things, the effectiveness of the drug has not yet been established, which raises some vague doubts. With all this, not every person knows what causes infertility, and why this happens, we will learn from this article. Kagocel belongs to the interferon group, it is designed to stimulate the production of its own interferon in the body. The annual sales volume of this medicine is more than 2.5 billion rubles.

According to reliable information, it became known that the manufacturer Rosnan is investing in this remedy about 1.2 billion rubles annually. Kagocel contains gossypol, there is a lot of interesting information about it, but there are reliable facts that have been confirmed by scientists and this is the essence. Chinese scientists found that men who ate food with cottonseed oil faced such an unpleasant pathology as infertility.

Not everyone knows that back in 1929, gossypol was used in contraceptives, which were very popular because they were considered more effective than other contraceptives. This discovery led the Chinese to create a whole study on the effectiveness of gossypol. But in 1986, due to frequent side effects, scientists had to abandon the idea of using it.

It was found that in 20% of men, from the use of such a medication, irreversible infertility appeared. In 1998, the WHO ordered the suspension of any research concerning him. It was found that it causes not only an adverse reaction, but is also highly toxic. Therefore, no other manufacturer considered it as a contraceptive.

In the composition of kagocel, 20% is "filled" with gossypol, of which only 3% are combined. No studies have been conducted, it is allowed to take 10 mg per day. The instructions for use of Kagocel clearly state that this remedy should not be used by children under six years of age.

Oddly enough, it is actively promoted by many doctors and pediatricians, despite its huge list of side effects.

Be sure to read the active ingredient included in the composition.
Look for a description on the English site.
See the instructions for use, in which cases it is prescribed.
Read online reviews about it. medicine for which diseases it is more effective.
Buy only from an authorized seller, as fakes are very common.

Kagocel was created at the research institute, and around 2000 the first tests were carried out. And in the year 2003, Kagocel was officially registered under the original name, which you all know. In 2005, Kagocel began to be produced as a full-fledged medicine. In 2013, Kagocel was already sold everywhere and gained popularity among other drugs in this segment.

I would like to note that the drug was tested only one single time. Approximately 1000 people took part in this trial, placebo-controlled studies of the effectiveness of the drug were made. However, these studies were performed with non-compliance with established standards. Among other things, these studies were criticized for violating the law regarding surveys on military personnel. There is no information about the drug on the official website dedicated to clinical trials. Therefore, each patient must decide for himself whether he needs it or not. We emphasize that all clinical trials were published exclusively in the Russian literature. It has never been used abroad, there is no information about this medication in the World Health Organization.

The drug stimulates the production of interferon, provides an antiviral effect. Before today no research has been done. Therefore, it is impossible to talk about effectiveness, you can only start from reviews on the Internet about this drug.

The manufacturer assures everyone that Kagocel causes the so-called production of interferon. When consumed orally, the drug reaches its effectiveness after two days. After a day, the drug accumulates to a large extent in the liver and is excreted naturally. There is a small concentration in the heart, as well as the brain and blood.

With daily intake of the drug inside, the substance accumulates in all these organs in a greater concentration. From the body, the drug is usually excreted naturally through the intestines a week after application.

When prescribing a drug in therapeutic dosages, it is not toxic, does not have any mutagenic properties. The effectiveness of the drug during therapy from the fourth day of the disease was noticed. According to doctors, it is taken from any day of infection. Most often it is prescribed for severe influenza illness.

Inhibition of spermatogenesis.
Male infertility.
Headache.
Nausea.
Vomiting and diarrhea (overdose).

According to the manufacturer, the medicine is not toxic and does not pose any danger to humans.

Gossypol undergoes a chemical change before use, so it is not dangerous. The manufacturer declares that the drug is classified as low-toxic and does not cause pathological changes. It should be said that the manufacturer agrees with the possibility of the manifestation of gossypol, but this happens extremely rarely.

The instructions for use say that the drug is well absorbed from the stomach, and its bioavailability is approximately 20%. A day later, it is completely distributed throughout the human body. But at the same time, absolutely nothing is written about him by a motorbike. Note that 80% of the drug is excreted by the intestines, and 20% is excreted by the kidneys.

In animal experiments, no negative effects on spermatozoa were found. However, administration of the substance to rats resulted in cyst formation in the tail region. Therefore, it makes no sense to talk about the safety of the drug, each person must determine for himself whether he needs it or not, because there are two opinions on the Internet about this: some say that the remedy helps with infectious diseases.

To date, the drug is actively promoted by all medical institutions for patients from three to six years old and adults. With all this, there are no clinical trials of safety.

Since the effects of this medication have not been monitored by the manufacturer, it is generally recommended with caution in adolescents and young children.

We recommend buying similar antiviral drugs with good reviews for viral diseases.

Lactose deficiency.
Age category.
Lactose intolerance.
Pregnancy.
Breastfeeding period.
Allergy.

There is information on the official forum on medicine that this medication reduces potency with prolonged use. It is usually prescribed during the treatment of herpes zoster and as an antiviral agent.

Every year, about five hundred million people become infected with influenza, about five hundred thousand patients die. In the first three months of the strongest epidemic, more than ten thousand people died worldwide. This is truly a terrible statistic, because the attention of all researchers over the past ten years has led to the production of anti-flu drugs. Since 2007, we have registered more than twenty drugs against this virus in Russia. Interesting, why is this happening? Some of the funds immediately receive permission to purchase without a prescription, others begin to actively advertise on television, but nowhere do they talk about the composition of the medicine and what it was previously used for, we decided to give a description of the most advertised medicines of today for the flu virus.

The manufacturer is Valenta, the active substance is pentanedioic acid. The manufacturer claims that it is antiviral. In 2008, Ingavirin was registered as a treatment for influenza. It should be noted that on April 12, 2010, the main substance Ingavirin was part of Dicarbamine, which was prescribed to cancer patients. And if you compare these two drugs, then they are completely different in action.

The instructions for Ingavirin indicate that it scans all cells and destroys only those that are infected. However However, in studies on the activity of Ingavirin, it was found that its concentration is not capable of destroying viruses. So what is Ingavirin? And how is it different from Dicarbamine? Nothing is completely clear, therefore, before using it, you need to think about how they treated cancer patients at first, and now it has become antiviral.

Anaferon. The active substance is antibodies to human interferon gamma. It appeared on the drug market back in 2002, anaferon is an immunomodulating drug, it is produced for both children and adults, although the difference between them is minimal, this is a kind of commercial move.

Vasily Vlasov, professor at the Higher School of Economics, president of the Society for Evidence-Based Medicine Specialists.

This is not the first flu season, having obeyed the Ministry of Health and Rospotrebnadzor, the Russians are buying the dubious drug Kagocel. Massive television and other advertising has a particularly strong influence on them. Let's see what Kagocel is and whether it is worth trusting the manufacturer's advertising.

How to check the activity of drugs and how to check Kagocel

Throughout the civilized world without the results of randomized clinical research(RCTs) do not allow the use of any drug. The essence of such tests is simple: sick people are divided into two groups, one is given medicine, the other is not. If the drug group recovers faster, the drug is approved.

Manufacturers of Arbidol, Atorvastatin, Dexamethasone and other drugs are conducting RCTs to prove their effectiveness. What benefits of Kagocel have been confirmed by RCTs?

We use the best and free information. On the pubmed.gov website, enter “kagocel AND randomized controlled trial” in the search bar. The first part selects all publications mentioning Kagocel, the second - all RCTs. We get 12 articles mentioning Kagocel. Not a single RCT.

If you dig deeper, it turns out that in some Russian magazines there is still a mention of two simple blind RCTs of Kagocel. They are very small (one has 81 adults, the other has 60 children). The quality of such studies is questionable.

Antiviral

The Ministry of Health of Russia recommends Kagocel "for the treatment and prevention of SARS (acute respiratory viral infections) and influenza, as well as for the treatment of herpes." It turns out that a healthy person will not get sick, but a sick person will recover. As we have seen, there is no conclusive evidence for the effectiveness of Kagocel. Just please don't confuse symptomatic remedies that only relieve the symptoms and remedies that cure the disease (earlier recovery)! It has not been proven that Kagocel supposedly prevents flu complications. Not everyone knows that every year hundreds of people in the country die from flu complications.

Side effects of Kagocel

The Kagocel molecule consists of two parts: carboxymethylcellulose (CMC) and gossypol.

CMC is the foundation detergents and wallpaper paste.

Gossypol is a substance of plant origin. Before the advent of Kagocel, it was mainly studied because it suppresses reproductive function men. At one time they even wanted to use gossypol as a contraceptive. They were afraid of its toxic effects and the fact that the suppression of spermatogenesis in men can be very long. The toxicity of gossypol is analyzed in their article by E. Ushkalova and N. Chukharev.

How are manufacturers of Kagocel protected? It is claimed that the gossypol in the preparation is contained in a bound form and is not dangerous. How do they prove it? Experiments on mice! But over the long years of Kagocel's existence, no one has shown us the results of human studies.

Kagocel actively produces interferons in the body. These are substances that animal cells secrete when infected, intoxicated, or damaged. It turns out that by forcing cells to produce interferons, you can protect them from the virus. Everything seems to be logical. Only studies do not confirm this. We still don't have proof.

It is not known whether Kagocel protects against influenza and SARS or not. It is unknown if he is dangerous or not.

The logical question is why was Kagocel allowed to be sold without a prescription? All over the world, only safe and well-studied medicines are sold this way. Another question - how did the toxic drug end up on the List of Essential Medicines? Drug manufacturers are seeking a place on this List, as sales are noticeably increased by this ...

Merkulova L. N. et al. Therapeutic efficacy of Kagocel ... Klin. pharmacol. therapy., 2002. 11(6):21-3

Kharlamova F. S. et al. Clinical efficacy of the drug Kagocel ... Children's infections, 2010. (4): 1-7.

E. Ushkalova, N. Chukhareva. Top sellers of over-the-counter drugs and problems of their safety. Doctor, 2014. (9)